Incorporation of radioactive L-cystine by normal and leukemic leukocytes in vivo.

Studies on analogues of L-cysteine and L-cystine. III. The effect of selenium cystine on leukemia.

-CYSTEINE and related (omnpoumsds appear to have au importatit uole in the rnetabolismn of leukocytes. 6 A decrease its the availability of L-cyst-eine or L_cystimie* may therefore have important effects ots beukocyt-es. The Icukocytes of acute leukemia amid chromuic myeloid beukemia exhibit a niore rapid turmiover of radioactive L-cystiise thams do normnal leukocytes.7’ 8 Leukensic leukocytes ...

Studies on analogues of L-cysteine and L-cystine. I. Some structural requirements for inhibiting the incorporation of radioactive L-cystine by leukemic leukocytes.

The effect of 6-mercaptopurine on the incorporation of labeled amino acids into cellular protein of chronic granulocytic leukemia leukocytes.

F RANTZ afl(l Zamecnik’ I)oiIlLe(l out that in vitro incorporation of C’4-leucine and C’4-alanine into white cell proteins was about six times greater in acute leukemic cells, as compared with normal leukecytes. Similar findings were obtained by \Veisberger et ;il23 using S35LcyTstii e and S 5-L-methionine. Baker, Zaniecnik and Stephenson4 showed that cells from cases of chronic’ Invelogenous l...

The incorporation of radioactive phosphorus into the phospholipids of human leukemic leukocytes and platelets.

The phospholipid composition of human platelets and erythrocytes has been reported by several investigators (1-4) and the metabolism of phospholipids in human blood has been studied in some detail (5-9). Recent investigations of phospholipid metabolism of leukocytes have been reported (6, 10) but we are not aware of similar studies on platelets. In this laboratory, investigation of the biochemi...

In vitro incorporation of C14-DL-leucine into normal and leukemic white cells.

By W. H. BAKER, P. C. ZAMECNIK AND M. L. STEPHENSON I N 191 1, Grafe demonstrated that hunsams leukemssic heukocytes possessed an oxidative metabolisns.’ Since that time, many comparative studies on tiormal amid leukemic humisan leukocytes have revealed major quantitative differetsces in their biochemical amid emizynsatic comsstituemits. 5 Details of these differences may be foumid iii the re(’...